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2-in-1 (Avanafil/Tadalafil)
Combination therapy providing both fast-acting (Avanafil) and long-lasting (Tadalafil) effects for comprehensive erectile dysfunction treatment.
What is the FDA-approved use of Avanafil/Tadalafil combination?
This combination contains two PDE5 inhibitors that work together:
- •Avanafil provides rapid onset of action (15-30 minutes) for spontaneous sexual activity.
- •Tadalafil provides extended duration of action (up to 36 hours) for flexibility in timing.
- •Combined therapy for men with severe erectile dysfunction who don't respond to single-agent therapy.
Limitations of Use:
- •This combination is not FDA-approved and is used off-label.
- •Not recommended for men with cardiovascular disease.
- •Not suitable for daily use due to increased side effect risk.
This combination should only be used under strict medical supervision with regular cardiovascular monitoring.
Who should not use Avanafil/Tadalafil combination?
Do not use this combination if:
- •You are taking nitrates, alpha-blockers, or guanylate cyclase stimulators.
- •You have severe cardiovascular disease, uncontrolled hypertension, or recent stroke/heart attack.
- •You have liver or kidney impairment.
- •You are taking CYP3A4 inhibitors (certain antibiotics, antifungals).
- •You have a history of priapism or bleeding disorders.
How should Avanafil/Tadalafil combination be administered?
Take no more than one tablet in a 48-hour period. This extended interval is necessary due to the combination's prolonged effects and increased risk profile.
Critical: Never exceed the recommended dose. The combination significantly increases the risk of dangerous side effects compared to single-agent therapy.
Side Effects Information
Common Side Effects
Dermatologic
- •Flushing (15% to 25%)
Neurologic
- •Headache (40% to 55%)
- •Dizziness (8% to 12%)
Gastrointestinal
- •Indigestion (10% to 18%)
Musculoskeletal
- •Back pain (15% to 20%)
- •Muscle pain (10% to 18%)
Respiratory
- •Nasal congestion (10% to 20%)
Ophthalmic
- •Visual disturbances (5% to 10%)
Serious Side Effects
Cardiovascular
- •Severe hypotension
- •Myocardial infarction
- •Stroke
- •Arrhythmias
Reproductive
- •Priapism (prolonged erection)
Ophthalmic
- •Sudden vision loss (NAION)
Otic
- •Sudden hearing loss
Contact Information
Reach out to our support team for any questions or assistance.
Email:
support@goliferx.md
Phone:
(609) 201-0119
This is an off-label combination therapy. Please consult your healthcare provider for complete safety information.