Important Safety Information for Spironolactone & Minoxidil (LoxOral®)
Hair Loss

Spironolactone & Minoxidil (LoxOral®)

Powerful combination therapy combining spironolactone's anti-androgen effects with minoxidil's growth-stimulating properties for comprehensive hair loss treatment.

What is the FDA-approved use of Spironolactone & Minoxidil combination?

This combination therapy provides:

  • Spironolactone blocks androgen receptors and reduces DHT effects on hair follicles.
  • Minoxidil stimulates hair growth through improved blood flow to follicles.
  • Combined therapy for androgenetic alopecia resistant to single-agent treatment.

Limitations of Use:

  • Requires intensive monitoring of cardiovascular and hormonal parameters.
  • Not suitable for patients with heart, kidney, or hormonal disorders.
  • May cause significant hormonal and cardiovascular side effects.

This combination requires specialized medical supervision with regular laboratory monitoring.

Who should not use Spironolactone & Minoxidil combination?

Do not use this combination if:

  • You have heart disease, kidney disease, or liver disease.
  • You have hormonal disorders or are taking hormonal medications.
  • You have electrolyte imbalances or are on potassium supplements.
  • You are pregnant or breastfeeding.
  • You have a history of gynecomastia or breast cancer.

How should Spironolactone & Minoxidil combination be administered?

Take exactly as prescribed, usually with food to reduce stomach upset. Maintain consistent timing of doses.

Critical: Regular blood tests for electrolytes, kidney function, and cardiovascular monitoring are required throughout treatment.

Side Effects Information

Common Side Effects

Cardiovascular

  • Fluid retention (15% to 25%)
  • Increased heart rate (10% to 18%)

Hormonal

  • Breast tenderness (10% to 20%)
  • Menstrual irregularities (15% to 30%)

Dermatologic

  • Unwanted body hair growth (70% to 80%)

Neurologic

  • Dizziness (8% to 15%)

Gastrointestinal

  • Nausea (5% to 10%)

Serious Side Effects

Cardiovascular

  • Heart failure
  • Severe hypotension
  • Pericardial effusion

Metabolic

  • Hyperkalemia (dangerous potassium levels)

Hormonal

  • Gynecomastia
  • Severe hormonal imbalances

Renal

  • Kidney function deterioration

Contact Information

Reach out to our support team for any questions or assistance.

This is a high-risk combination therapy requiring specialized medical supervision and regular monitoring.