Important Safety Information for 2-in-1 (Vardenafil/Tadalafil++)
Sexual Health

2-in-1 (Vardenafil/Tadalafil++)

Enhanced combination formula providing rapid onset with extended duration, formulated for men requiring intensive erectile dysfunction therapy.

What is the FDA-approved use of Vardenafil/Tadalafil combination?

This enhanced combination provides dual PDE5 inhibition:

  • Vardenafil provides potent erectile response with intermediate onset (30-60 minutes).
  • Enhanced Tadalafil provides extended duration (up to 36 hours) with improved potency.
  • Reserved for severe erectile dysfunction cases unresponsive to standard therapy.

Limitations of Use:

  • This is an off-label, high-risk combination not FDA-approved for routine use.
  • Contraindicated in men with any cardiovascular disease.
  • Requires intensive medical monitoring and regular cardiovascular assessment.

This combination should only be prescribed by specialists experienced in high-risk ED management.

Who should not use Vardenafil/Tadalafil combination?

Do not use this combination if:

  • You have any cardiovascular disease, hypertension, or history of stroke/heart attack.
  • You are taking nitrates, alpha-blockers, or any blood pressure medications.
  • You have liver disease, kidney disease, or are over 65 years old.
  • You are taking any medications that affect heart rhythm or blood pressure.
  • You have a history of priapism, bleeding disorders, or retinal problems.

How should Vardenafil/Tadalafil combination be administered?

Take no more than one tablet in a 72-hour period. This extended interval is critical due to the combination's high potency and prolonged effects.

Emergency Warning: If you experience chest pain, dizziness, or prolonged erection, seek immediate medical attention. Do not take additional doses.

Side Effects Information

Common Side Effects

Dermatologic

  • Severe flushing (20% to 30%)

Neurologic

  • Intense headache (45% to 60%)
  • Dizziness (15% to 25%)

Gastrointestinal

  • Severe indigestion (15% to 25%)

Musculoskeletal

  • Severe back pain (20% to 30%)

Cardiovascular

  • Palpitations (10% to 15%)

Respiratory

  • Severe nasal congestion (15% to 25%)

Ophthalmic

  • Visual disturbances (8% to 15%)

Serious Side Effects

Cardiovascular

  • Dangerous hypotension
  • Heart attack
  • Stroke
  • Life-threatening arrhythmias

Reproductive

  • Priapism requiring emergency treatment

Ophthalmic

  • Permanent vision loss

Otic

  • Permanent hearing loss

Contact Information

Reach out to our support team for any questions or assistance.

This is a high-risk, off-label combination. Requires specialized medical supervision.